Journal of tuberculosis research jtr is an openly accessible journal published quarterly. Mycobacterium tuberculosis tb is an insidious scourge that has afflicted humans for thousands of years, and still remains one of the leading causes of death in the world, now estimated at 1. Pubmed central scopus sciencedirect directory of open access journals doaj editorial board. Mycobacterium tuberculosis is a human pathogen that has had a staggering global impact. Laboratory diagnosis of mycobacterium tuberculosis.
Tobacco smoke increases the risks of mycobacterium tuberculosis infection, of severe tb and death from tb. These bacteria are acidfast, aerobic, nonspore forming, nonmotile bacteria 1. Tuberculosis is a speciality journal focusing on basic experimental research on tuberculosis, notably on bacteriological, immunological and pathogenesis aspects of the disease. The diagnosis of tuberculosis in developing countries still relies on direct sputum examination by light microscopy, a method that is easy to perform and that is widely applied. International journal of tuberculosis and lung disease the union. Tb, tuberculosis, mycobacterium tuberculosis complex mtbc characteristics. Tuberculosis airborne disease caused by the bacterium mycobacterium tuberculosis m. Mycobacterium tuberculosis gene expression studies have involved in vitro, ex vivo and in vivo experiments animal models, but without the expected success. In the murine model of infection, a mycobacterium tuberculosis mce1 operon mutant elicits an aberrant granulomatous response, resulting in uncontrolled replication and failure to enter a persistent state. It is distributed in over 165 countries worldwide to physicians, health workers, researchers, professors, students and decisionmakers, including public health. The journals main aim is the continuing education of physicians and other health personnel, and the dissemination of the most uptodate information in the field of tuberculosis and lung health. An estimated 17% of all tuberculosis cases in ethiopia are caused by mycobacterium bovis.
Pdf the biology of mycobacterium tuberculosis infection. A positive result indicates that a person has been infected with the tuberculosis bacteria at some point in his or her life. The classical view of the mycobacterial cell wall structure has been revised thanks to. Thus, successful treatment of tuberculosis has benefits both for the individual patient and. Detection and molecular characterization of 9000yearold. Mycobacterium tuberculosis is the etiological agent of tuberculosis tb, the leading cause of death due to a single infectious agent, claiming 1. Hence, it becomes imperative to focus on novel drug targets. International journal of mycobacteriology free full text.
The biology of mycobacterium tuberculosis infection. More than 95% of tuberculosis deaths occur in low and middle income countries. Molecular epidemiology of mycobacterium tuberculosis complex in brussels. Mycobacterium tuberculosis an overview sciencedirect. The aim of the tuberculosis journal is to share the recent developments in the research on tuberculosis with the peers and also the masses as well to spread awareness. We have recently found that selected thiodisaccharides possess bactericidal effects against mycobacterium tuberculosis but not against escherichia coli or staphylococcus aureus. Pyrrolidine carboxamides as a novel class of inhibitors of. The biology of mycobacterium tuberculosis infection ncbi. The effect of pyrazinoic acid poa 500 mgl, 4 mm on protein a and rna synthesis b as measured by the amount of radioactive 35 smethionine or 3 huracil associated with the tubercle bacilli counts per minute, c. The causative agents of tb are a group of closely related bacteria known as. Mycobacterium tuberculosis high impact list of articles ppts journals 11593. Revell journal of clinical microbiology may 2016, 54 6 14341441. Guide for authors journal of clinical tuberculosis and.
Pulmonary tuberculosis tb remains a major cause of morbidity and mortality worldwide, with about onethird of the worlds population infected. Journal of clinical tuberculosis and mycobacterial diseases is an open access publication. Raffa, in molecular medical microbiology second edition, 2015. The prevailing multidrug resistance in mycobacterium tuberculosis continues to remain one of the main challenges to combat tuberculosis. A better knowledge of the mechanisms of drug resistance of m. The cells are impervious to grams staining gram negative staining in clinical lab. Depending on the environment, these tiny particles can remain.
In view of the worldwide spread of multidrug resistance of mycobacterium tuberculosis, there is an urgent need to discover antituberculosis agent with novel structures. Infectious droplet nuclei are generated when persons who have pulmonary or laryngeal tb disease cough, sneeze, shout, or sing. The bacteria usually attack the lungs, but they can also damage other parts of the body. Journal of mycobacterial diseases is one of the best open access journals of scholarly publishing. The bacterium is an acid fast bacillus with unique cell wall. Mtb is a slow growing mycobacteria with a doubling time of 1224 h under optimal conditions. Mycobacterium tuberculosis list of high impact articles. Some species of the mycobacterium tuberculosis complex mtbc, particularly mycobacterium tuberculosis, which causes human tuberculosis tb, are the first cause of death linked to a single pathogen worldwide. Mycobacterium tuberculosis and mycobacterium tuberculosis complex including m. According to nextgeneration sequencing, four of six analyzed mutants which were resistant to high. Mycobacterium tuberculosis molecular determinants of.
Mycobacterium is covered by a waxy layer on its surface due to the presence of mycolic acid. Mycobacterium tuberculosis was discovered and described by robert koch on 24 march 1882, about years ago, as the causative agent of tuberculosis tb. Tb spreads through the air when a person with tb of the lungs or throat coughs, sneezes, or talks. Mycobacterium tuberculosis culture from specimen is the cornerstone. Regulation of the mycobacterium tuberculosis mce1 operon. Grams staining gram negative staining in clinical lab. However, because of its poor sensitivity and requirement for significant labor and training, light microscopy examination detects the bacilli in only 45 to 60% of all people whose specimens are culture positive for. If you have been exposed, you should go to your doctor for tests. Autofluorescence of mycobacteria as a tool for detection. Journal of clinical tuberculosis and other mycobacterial. In the last decades, evolutionary studies have much improved our knowledge on mtbc history and have highlighted its long coevolution with humans. A major feature of mtb is the peculiar cell wall structure, that provides an exceptionally strong impermeable barrier to noxious compounds and drugs and that plays a fundamental role in virulence.
The remaining patients will have latent tb, which can advance to active infection in times of immunosuppression. Tuberculosis tb is the number one cause of human death due to an infectious disease. Ecology and evolution of mycobacterium tuberculosis. The overall goals for treatment of tuberculosis are 1 to cure the individual patient, and 2 to minimize the transmission of. Spinal deformities typical of those resulting from m. The strengths, weaknesses, opportunities and threats. Mycobacterium tuberculosis is a bacterium that causes tuberculosis tb in humans.
Main articles welcome to south sudan medical journal. International journal of tuberculosis and lung disease. The diagnosis of pulmonary tuberculosis precision and future. Selection pressure that is caused by misuse of antituberculosis drugs. Its situation is worsened by the presence of multidrug resistant mdr strains of mycobacterium tuberculosis, the causative agent of the disease. Effect of isoniazid preventive therapy on tuberculosis prevalence among hiv patients attending bahati.
Tuberculosis tb is a serious public health problem worldwide. International journal of tuberculosis and lung disease ijtld the international journal of tuberculosis and lung disease ijtld is the official publication of the international union against tuberculosis and lung disease the union. The official journal of the international union against tuberculosis and lung. Metabolic switching of mycobacterium tuberculosis during. Tuberculosis tb is a disease caused by bacteria called mycobacterium tuberculosis. Here, we selected spontaneous mutants displaying resistance against the investigated thioglycoside. Effect of pyrazinoic acid and pyrazinamide on protein and rna synthesis in m. Drug resistance mechanisms in mycobacterium tuberculosis. Mycobacterium tuberculosis pathogenesis and molecular. Tuberculosis tb still constitutes a major public health challenge due to its high mortality and morbidity rates 1. Articles from mediterranean journal of hematology and infectious. When inhaled, the bacterium can settle in the lungs, where it. This is supported by skeletal evidence of the disease in early humans, and inferred from m.
Editorinchief zelalem temesgen, mayo clinic rochester, rochester, minnesota, united states. In recent years, even more serious forms of drug resistance have been reported. Mycobacterium tuberculosis can appear red in colour on acid fast staining. Tb is caused by members of the specie mycobacterium tuberculosis. Chapter 2 transmission and pathogenesis of tuberculosis. Journal mainly focus on clinical research and epidemiological studies on tuberculosis, drug resistance during therapy. Journal of clinical tuberculosis and mycobacterial diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including but not limited to epidemiology, clinical investigation, transmission, diagnosis, treatment, drugresistance and public policy, and encourages the. Journal of clinical tuberculosis and other mycobacterial diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including but not limited to epidemiology, clinical investigation, transmission, diagnosis. Mycobacterium tuberculosis list of high impact articles journals. A fundamental question in mycobacterial physiology is to understand the mechanisms involved in hypoxic stress, a critical player in persistence.
The international journal of tuberculosis and lung disease is an official journal of the union. Inha, the enoyl acyl carrier protein reductase enr from m. Mycobacterial diseases is a scientific journal deals with diseases caused by mycobacterium species chiefly tuberculosis, leprosy and research on remedial methods for these diseases. It is actively secreted but partly attached to the surface of the mycobacterial cell by a lipid tail that may also be responsible for binding of carbohydrate to the protein. This study looks at the construction of a global protein. Of the deaths attributable to tb in 2016, 22% occurred in people coinfected with hiv, and close to 5% of the 10. Tuberculosis tb is an airborne infectious disease caused by organisms of the mycobacterium tuberculosis complex. Mycobacterium tuberculosis retains the ability to establish an asymptomatic latent infection. The new engl and journal of medicine 746 n engl j med 368. The intracellular pathogen mycobacterium tuberculosis mtb is the main cause of human tuberculosis. It has no environmental reservoir and is believed to have coevolved with its host over millennia. Tuberculosis tb is definedas a disease caused by members of the m.
Background mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It was first discovered by robert koch in the year 1882. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of tuberculosis research. All correspondence, including notification of the editors decision and requests for revision, is sent by email. The journal will cover technical and clinical studies related to health, ethical and social issues in field of clinical and epidemiological studies of mycobacterial infection, microbiology of mycobacterium, epidemiology of mycobacterium, molecular biology of mycobacterium, clinical features of mycobacterium. Journal of tuberculosis emphasizes on the importance of a patientcentered approach in order to foster the right adherence among the tuberculosis patients. Journal of tuberculosis and therapeutics open access journals.